Autoresuscitation after pediatric cardiac arrest: is hyperventilation a cause?
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Updated: Jun 3, 2026

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Published on: January 30, 2020
Jonathan P Duff1, Ari R Joffe, William Sevcik
1Department of Pediatrics, University of Alberta and Stollery Children's Hospital, Edmonton, Alberta, Canada. jon.duff@albertahealthservices.ca
Insights
The Lazarus phenomenon, a delayed return of spontaneous circulation, is reported in two children following resuscitation. Unintentional hyperventilation during cardiopulmonary resuscitation may be the cause.
Area of Science:
- Pediatric critical care medicine
- Emergency medicine
- Cardiology
Background:
- The Lazarus phenomenon, or autoelection, is the spontaneous return of circulation after failed cardiopulmonary resuscitation.
- While documented in adults, this phenomenon has not been previously reported in pediatric cases.
Observation:
- Two pediatric patients experienced the Lazarus phenomenon after pulseless arrest.
- Both cases occurred in the context of cardiopulmonary resuscitation (CPR).
Findings:
- The Lazarus phenomenon was observed in pediatric patients, expanding its known occurrence.
- Unintentional hyperventilation during resuscitation is hypothesized as a potential contributing factor.
Implications:
- This report highlights the need to consider the Lazarus phenomenon in pediatric resuscitation.
- Further investigation into the mechanisms and management of pediatric Lazarus phenomenon is warranted.
- Clinicians should be aware of potential causes, such as hyperventilation, during pediatric CPR.
Abstract:
There are a number of reports of delayed return of spontaneous circulation after pulseless arrest (the Lazarus phenomenon) in adults. There are no published reports of this phenomenon in children. We report 2 pediatric cases of the Lazarus phenomenon, likely caused by unintentional hyperventilation during resuscitation.
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