Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Controlling nanoparticle targeting: from physicochemical design to molecular recognition.

Nanomedicine (London, England)·2026
Same author

Profile of John Clarke, Michel H. Devoret, and John M. Martinis: 2025 Nobel laureates in Physics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Targeting the αvβ5 Integrin Modifies the TGF-β-Rich Tumor Microenvironment of Pancreatic Cancer.

Cancer research·2026
Same author

Intravenous galanin (1-16) and a GalR1 agonist attenuate allodynia in rats with spared nerve injury.

Pain reports·2026
Same author

The 2026 guided acoustic waves roadmap.

Journal of physics D: Applied physics·2026
Same author

LSTA1-GBM-2A: study protocol for an exploratory phase 2a randomised controlled trial evaluating tumour-homing peptide certepetide with temozolomide in glioblastoma multiforme.

BMJ open·2025
Same journal

Near-exceptional point degeneracy enables multilevel optical memory.

Nature nanotechnology·2026
Same journal

Monolithic manufacturing of an electrically addressable quasi-suspended nanophotonic aperture.

Nature nanotechnology·2026
Same journal

Halide-site-substituting spacer creates quasi-two-dimensional perovskites for vapour-deposited light-emitting diodes.

Nature nanotechnology·2026
Same journal

Nanoscale amorphization of poly(triarylamine) for efficient and stable inverted perovskite photovoltaics.

Nature nanotechnology·2026
Same journal

Bridging nanotechnology and mechanobiology.

Nature nanotechnology·2026
Same journal

Coherent 2D/3D van der Waals epitaxy enables single-crystal perovskite heterostructures.

Nature nanotechnology·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison
07:08

Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison

Published on: October 20, 2020

A high-throughput label-free nanoparticle analyser.

Jean-Luc Fraikin1, Tambet Teesalu, Christopher M McKenney

  • 1Department of Physics, University of California Santa Barbara, California 93106, USA.

Nature Nanotechnology
|March 8, 2011
PubMed
Summary
This summary is machine-generated.

A new microfluidic analyzer offers high-throughput physical characterization of nanoparticles and viruses. This tool analyzes individual particles at 500,000 per second, enabling rapid sizing and concentration analysis in complex mixtures and biological samples.

More Related Videos

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
09:09

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Related Experiment Videos

Last Updated: Jun 3, 2026

Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison
07:08

Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison

Published on: October 20, 2020

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
09:09

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Area of Science:

  • Nanotechnology
  • Biophysics
  • Analytical Chemistry

Background:

  • High-throughput analytical tools are needed for characterizing synthetic nanoparticles and genetically modified viruses.
  • Current methods lack the speed and sensitivity for complex, unlabelled nanoparticle suspensions.

Purpose of the Study:

  • To develop and demonstrate a microfluidic analyzer for high-throughput physical characterization of individual nanoparticles and viruses.
  • To enable rapid sizing, concentration analysis, and titre determination of unlabelled nanoparticle suspensions.

Main Methods:

  • Development of a novel microfluidic analyzer capable of detecting and characterizing individual nanoparticles.
  • Demonstration of particle detection, concentration analysis, and sizing in multicomponent mixtures at 500,000 particles/second.
  • Application of the analyzer for rapid size and titre analysis of unlabelled bacteriophage T7 in salt solution and mouse blood plasma.

Main Results:

  • The microfluidic analyzer achieved high-throughput detection and characterization of synthetic nanoparticles in complex mixtures.
  • Rapid size and titre analysis of unlabelled bacteriophage T7 was performed using minimal sample volumes (~1 × 10⁻⁶ l).
  • A significant background of naturally occurring nanoparticles with a power-law size distribution was unexpectedly discovered in native blood plasma.

Conclusions:

  • The presented microfluidic analyzer provides a powerful tool for high-throughput physical characterization of nanoparticles and viruses.
  • Its scalability, simple electronics, and high detection capability make it suitable for diverse applications in nanotechnology and biomedical research.
  • The discovery of background nanoparticles in blood plasma highlights the analyzer's sensitivity and potential for biological sample analysis.