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A bioinformatic assay for pluripotency in human cells

Franz-Josef Müller1, Bernhard M Schuldt, Roy Williams

  • 1Zentrum für Integrative Psychiatrie, Kiel, Germany. fj.mueller@zip-kiel.de

Nature Methods
|March 8, 2011
PubMed

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...