Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Factor V-specific circulating anticoagulant and enteropathy. 2 cases].

B Taillan1, J G Fuzibet, H Vinti

  • 1Service de Médecine interne I, Hôpital de Cimiez, Nice.

Presse Medicale (Paris, France : 1983)
|February 10, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Experimental Limit on the Permanent Electric Dipole Moment of the Deuteron.

Physical review letters·2026
Same author

Milk metabolomic alterations correlated with intramammary infection in dairy cows: From healthy status to clinical mastitis.

Journal of dairy science·2026
Same author

Furcate cord insertion: under-reported but likely relevant.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2023
Same author

Swab test in biological fluids as predictor of COVID-19 transmission risk during surgery: a prospective cross-sectional study from an Italian COVID center.

BMC surgery·2022
Same author

Microsurgical clipping versus newer endovascular techniques in treatment of unruptured anterior communicating artery-complex aneurysms: a meta-analysis and systematic review.

Neurosurgical review·2021
Same author

Short communication: Seroprevalence of paratuberculosis in Italian water buffaloes (Bubalus bubalis) in the region of Campania.

Journal of dairy science·2021
Same journal

Predictive analytics and risk stratification models in internal medicine: from risk scores to real-time machine learning.

Presse medicale (Paris, France : 1983)·2026
Same journal

Artificial Intelligence in skin disease therapeutics: from drug discovery to personalized treatment pathways.

Presse medicale (Paris, France : 1983)·2026
Same journal

AI in clinical diagnostics in dermatology: applications, validation, and real-world use cases.

Presse medicale (Paris, France : 1983)·2026
Same journal

Artificial Intelligence in medical research and publishing: progress, risks, and future perspectives.

Presse medicale (Paris, France : 1983)·2026
Same journal

Ethical, legal, and regulatory challenges in AI-based healthcare tools.

Presse medicale (Paris, France : 1983)·2026
Same journal

Decision-making for clinicians.

Presse medicale (Paris, France : 1983)·2026
See all related articles

Two patients developed a Factor V inhibitor, an autoimmune condition, linked to flare-ups of coeliac and Crohn's diseases. The inhibitor appeared and disappeared with disease activity, suggesting an autoimmune cause.

Area of Science:

  • Gastroenterology
  • Immunology
  • Hematology

Background:

  • Factor V inhibitors are rare autoimmune clotting disorders.
  • Coeliac disease and Crohn's disease are chronic inflammatory gastrointestinal conditions.
  • The association between autoimmune disorders and acquired coagulation factor inhibitors is not fully understood.

Observation:

  • Two patients with coeliac disease and Crohn's disease, respectively, developed Factor V-specific circulating anticoagulants.
  • The inhibitor's presence correlated with disease flare-ups and its absence with remission.
  • This pattern recurred in one patient after a year, strengthening the observed association.

Findings:

  • The autoimmune inhibitor of Factor V appeared and resolved in tandem with inflammatory bowel disease activity.

Related Experiment Videos

  • No bleeding complications were reported in either patient.
  • The absence of typical Factor V inhibitor causes suggests an autoimmune etiology.

    • Implications:

    • This case series suggests a potential link between inflammatory bowel diseases and the development of autoimmune Factor V inhibitors.
    • Further research is warranted to explore the immunopathogenesis of Factor V inhibitors in the context of gastrointestinal autoimmunity.
    • Understanding this association may inform diagnostic and therapeutic strategies for patients with coeliac or Crohn's disease and unexplained coagulopathy.