Related Experiment Video

Updated: Jun 3, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Growth of kidney-transplanted pediatric patients treated with sirolimus

David González1, Clotilde D García, Marta Azócar

  • 1Hospital Universitario Central de Asturias, Villamil s/n, 33006, Oviedo, Asturias, Spain.

Pediatric Nephrology (Berlin, Germany)
|March 8, 2011
PubMed

Insights

Sirolimus (SRL) treatment in kidney-transplanted children significantly reduces growth velocity and height compared to controls. This indicates SRL therapy may negatively impact growth in pediatric renal transplant patients.

Area of Science:

  • Pediatric Nephrology
  • Translational Medicine
  • Growth and Development

Background:

  • Sirolimus (SRL) is known to inhibit longitudinal growth, potentially via effects on cell proliferation and vascular endothelial growth factor (VEGF).
  • Understanding SRL's impact on growth is crucial for pediatric kidney transplant recipients.

Purpose of the Study:

  • To investigate the growth patterns of kidney-transplanted children treated with SRL.
  • To compare growth outcomes in SRL-treated children versus matched controls not receiving SRL.

Main Methods:

  • A multicenter observational clinical study involving 68 pediatric kidney transplant patients (34 SRL, 34 controls).
  • Measurements included height, change in height standard deviation (Δ height), and growth velocity at 0, 6, 12, and 24 months post-SRL initiation.
  • Controls were matched for age, gender, renal function, and corticosteroid dosage.

Main Results:

  • SRL treatment was associated with significantly lower growth velocity (cm/year) and smaller Δ height at 6, 12, and 24 months compared to controls (p < 0.05).
  • Nephrotoxicity was the primary reason for initiating SRL therapy.

Conclusions:

  • Sirolimus therapy appears to adversely affect the growth of kidney-transplanted children.
  • This finding necessitates consideration of SRL's impact on growth when switching treatments and warrants further prospective validation in larger cohorts.

More Related Videos

Robot-Assisted Kidney Transplantation07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

Murine Kidney Transplant Technique08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...