Azatides as peptidomimetics: solution and liquid phase syntheses

Peptidomimetics have become immensely important for both organic and medicinal chemists (1). The alteration of peptides to peptidomimetics has included peptide side chain manipulations, amino acid extensions (2), deletions (3), substitutions (1a,b), and most recently backbone modifications (4). It is this latter development that has been exploited for the synthesis of biomimetic polymeric structures. Such progress has been fueled by the suggestion that peptidomimetics may provide novel scaffolds for the generation of macromolecules with new properties of both biological and chemical interest (4).