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Changes in small intestinal motility in acute physical stress--an experimental study
P Parrilla1, P Ramirez, M S Muelas
1Departamento de Cirugia, Hospital Virgen de la Arrixaca, El Palmar, Murcia, Spain.
Hepato-Gastroenterology
|February 1, 1990
Summary
Acute physical stress alters small intestine motility, increasing it during fasting and decreasing it during early digestion. Adrenergic blockers prevent stress-induced hypomotility, while naloxone enhances it.
Area of Science:
- Gastroenterology
- Neurogastroenterology
- Physiology
Background:
- Understanding the impact of acute physical stress on gastrointestinal motility is crucial for managing digestive health.
- The roles of the adrenergic and beta-endorphinergic systems in mediating stress responses within the small intestine require further elucidation.
Purpose of the Study:
- To investigate how acute physical stress affects small intestine motility during fasting and post-prandial states.
- To determine the involvement of adrenergic and beta-endorphinergic systems in stress-induced alterations of intestinal motility.
Main Methods:
- Electromyography and manometry were used to record small intestine motility in 60 dogs.
- Plasma levels of beta-endorphin and catecholamines were measured before and after acute physical stress induction.
Main Results:
- Physical stress increased small intestine motility during fasting (phases I/II) and late post-prandial periods.
- Stress induced significant hypomotility during the early post-prandial period.
- Adrenergic blockers counteracted stress-induced hypomotility, while naloxone exacerbated it.
Conclusions:
- Acute physical stress differentially modulates small intestine motility based on the digestive state.
- The adrenergic system plays a key role in mediating the hypomotile response to stress.
- The beta-endorphinergic system may be involved in the hypomotility observed during stress.