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[Clinical efficacy of reamberine in therapy for influenza]

V A Isakov, L P Vodeĭko, I V Kabolova

    Terapevticheskii Arkhiv
    |March 9, 2011
    PubMed
    Abstract

    Insights

    Reamberine (RB) infusions effectively treat pneumonia-complicated influenza and acute respiratory diseases (ARD). This antioxidant therapy enhances immune resistance and clinical outcomes in patients with respiratory infections.

    Area of Science:

    • Medical Research
    • Pharmacology
    • Infectious Diseases

    Background:

    • Pneumonia-complicated influenza and acute respiratory diseases (ARD) pose significant clinical challenges.
    • Evaluating novel therapeutic agents for these conditions is crucial for improving patient outcomes.
    • Understanding the role of oxidative stress and antioxidant mechanisms in respiratory infections is essential.

    Purpose of the Study:

    • To assess the tolerance and therapeutic effectiveness of 1.5% reamberine (RB) solution infusions.
    • To investigate RB's impact on oxidative stress markers and antioxidant potential in patients with pneumonia-complicated influenza and ARD.
    • To compare RB's efficacy against other treatments and basic therapy.

    Main Methods:

    • A study involving 133 patients (aged 18-60) diagnosed with pneumonia-complicated influenza and ARD.
    • Monitoring of dynamic serum metalloprotein (MP) levels (transferrin, lactoferrin, ceruloplasmin) and superoxide dismutase activity.
    • Quantification of malondialdehyde (MDA) using the thiobarbituric acid test to assess lipid peroxidation.

    Main Results:

    • Intravenous RB infusions demonstrated a modifying effect on serum MP content.
    • RB significantly stabilized serum antioxidant potential, outperforming olifen and vitamin E.
    • Enhanced nonspecific protection and significant clinical improvement were observed in patients receiving RB.

    Conclusions:

    • 1.5% RB solution infusions (300 ml for 4-5 days) are highly clinically effective for pneumonia-complicated influenza.
    • RB treatment effectively stabilizes serum antioxidant potential.
    • RB enhances the body's nonspecific resistance, contributing to improved recovery from respiratory infections.

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