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Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells

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Published on: July 24, 2014

When are cellular oscillators sufficient for sequential segmentation?

Rebecca H Chisholm¹, Barry D Hughes, Kerry A Landman

¹Department of Mathematics and Statistics, University of Melbourne, Victoria 3010, Australia.

Journal of Theoretical Biology

|March 9, 2011

Summary

This summary is machine-generated.

Mathematical models reveal that cellular oscillators suffice for embryonic segmentation when cell division is posterior-restricted. A morphogen gradient is necessary when cell division is distributed, influencing somitogenesis patterns.

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Area of Science:

Developmental Biology
Mathematical Modeling
Cellular Dynamics

Background:

Embryogenesis involves sequential segmentation and axial elongation.
Cellular oscillators (segmentation clocks) are central to most segmentation models.
Oscillations are linked to physiological age or morphogen gradients.

Purpose of the Study:

Determine when cellular oscillators alone are sufficient for segmentation.
Investigate the necessity of morphogen gradients in segmentation.
Relate positional information acquisition to cell division patterns.

Main Methods:

Developed mathematical models of sequential segmentation.
Analyzed models with posterior-restricted versus distributed cell divisions.
Incorporated diffusion and non-diffusion mechanisms for morphogen gradients.

Main Results:

Models show oscillators suffice with posterior-restricted cell division.
Models indicate morphogen gradients are required for distributed cell division.
Simulated segment polarity and anterior-to-posterior segment size distribution.
Predicted segment deletions upon division interruption and presomitic mesoderm dynamics.

Conclusions:

Cell division distribution critically determines the mechanism of positional information acquisition.
Oscillators are sufficient if positional information is age-based (posterior division).
Morphogen gradients are essential if positional information relies on spatial cues (distributed division).