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Updated: Jun 3, 2026

Understanding Early Organogenesis Using a Simplified In Situ Hybridization Protocol in Xenopus
Published on: January 12, 2015
All the embryo's a stage, and Olig2 in its time plays many parts
Zachary B Gaber1, Bennett G Novitch
1Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Abstract:
Olig2 is essential for the selection of motor neuron and oligodendrocyte fates and the choice of neural progenitors to either proliferate or differentiate. Three new studies demonstrate that these diverse actions of Olig2 are gated by phosphorylation at two distinct motifs and that Olig2's proliferative function acts in opposition to the p53 tumor suppressor pathway.
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