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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This makes...
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...

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Updated: Jun 3, 2026

Gastrointestinal Motility Monitor (GIMM)
08:15

Gastrointestinal Motility Monitor (GIMM)

Published on: December 1, 2010

Colonic dysmotility in constipation.

Philip G Dinning1, Carlo Di Lorenzo

  • 1Department of Gastroenterology, University of New South Wales, St George Hospital, Gray St, Kogarah, NSW 2217, Sydney, Australia. P.Dinning@unsw.edu.au

Best Practice & Research. Clinical Gastroenterology
|March 9, 2011
PubMed
Summary
This summary is machine-generated.

This review explores colonic motor dysfunction in chronic constipation, highlighting how physiological testing aids in diagnosing and managing motility disorders in pediatric and adult patients.

Related Experiment Videos

Last Updated: Jun 3, 2026

Gastrointestinal Motility Monitor (GIMM)
08:15

Gastrointestinal Motility Monitor (GIMM)

Published on: December 1, 2010

Area of Science:

  • Gastroenterology
  • Colorectal Physiology
  • Motility Disorders

Background:

  • Constipation is a prevalent condition with significant morbidity and healthcare costs.
  • Colonic motor dysfunction is a primary hypothesis for severe chronic constipation.
  • Physiological testing is crucial for identifying dysmotility and guiding patient management.

Purpose of the Study:

  • To review the latest findings on colonic motility disorders in constipation.
  • To enhance understanding of colonic dysfunction in pediatric and adult populations.
  • To explore the role of physiological testing in diagnosing and managing constipation.

Main Methods:

  • Review of recent scientific literature on colonic motility and constipation.
  • Analysis of physiological testing methods for assessing colonic function.
  • Synthesis of findings related to pediatric and adult constipation.

Main Results:

  • Colonic motor patterns and transit measurements have advanced knowledge of colonic physiology.
  • Understanding of motility disorders associated with colonic dysfunction has improved.
  • Physiological testing is instrumental in identifying specific dysmotilities.

Conclusions:

  • Colonic motor dysfunction is central to severe chronic constipation.
  • Physiological testing is essential for accurate diagnosis and management.
  • This review consolidates current knowledge on constipation-related motility disorders.