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Updated: Jun 3, 2026

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Published on: November 9, 2019
Experimental validation of a new integrated simulated moving bed process for the production of single enantiomers
Javier García Palacios1, Bernhard Kramer, Achim Kienle
1Max-Planck-Institut für Dynamik komplexer technischer Systeme, D-39106 Magdeburg, Germany.
Abstract:
A new integrated 3-zone simulated moving bed (SMB) concept with internal racemization reaction was suggested recently for the production of single enantiomers from racemic mixtures [1,2]. The process utilizes an internal gradient to trigger the racemization within a single zone. It can deliver the pure enantiomer and outperforms conventional technologies. In this contribution, the concept is validated experimentally for the separation of a model system compound. The results demonstrate that the new concept is capable of producing a single enantiomer with purity, yield and conversion of 100%.
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