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Related Experiment Video

Updated: Jun 3, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Ulcerative cheilitis in a rhesus macaque.

C C Bailey1, A D Miller

  • 1New England Primate Research Center, Harvard Medical School, Division of Comparative Pathology, Southborough, MA 01772, USA. charles_bailey@hms.harvard.edu

Veterinary Pathology
|March 9, 2011
PubMed
Summary

A rhesus macaque infected with simian immunodeficiency virus developed a labial ulcer. Immunohistochemistry and DNA sequencing identified Macacine herpesvirus 1 (B virus) as the cause.

Area of Science:

  • Veterinary Pathology
  • Primate Virology
  • Infectious Diseases

Background:

  • Simian immunodeficiency virus (SIV) infection in rhesus macaques can lead to opportunistic infections.
  • B virus (Macacine herpesvirus 1) is a common herpesvirus in macaques, typically causing asymptomatic infection in its natural host.
  • Clinical signs in macaques can vary, and coinfections are possible.

Observation:

  • A 2-year-old female rhesus macaque with a history of SIV infection presented with diarrhea, weight loss, and a labial ulcer.
  • Histopathology of the ulcer revealed inflammation with neutrophils, macrophages, and syncytial epithelial cells.
  • Rare epithelial cells contained herpetic inclusion bodies.

Findings:

  • Immunohistochemistry confirmed the presence of Human herpesvirus 1 antigens in the affected epithelial cells.

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Published on: April 22, 2010

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Published on: April 22, 2010

  • DNA sequencing identified the causative agent as Macacine herpesvirus 1 (B virus), closely related to Human herpesvirus 1.
  • This case highlights a potential link between SIV infection and B virus reactivation or pathogenesis.

    • Implications:

    • This finding suggests that B virus can cause ulcerative lesions in SIV-infected macaques.
    • Understanding coinfections in SIV-infected primates is crucial for disease management and research.
    • Further investigation into the interplay between SIV and herpesviruses in macaques is warranted.