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Related Experiment Video

Updated: Jun 3, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Knuckle cracking and hand osteoarthritis.

Kevin Deweber¹, Mariusz Olszewski, Rebecca Ortolano

¹Department of Family Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. kdeweber@usuhs.mil

Journal of the American Board of Family Medicine : JABFM

|March 9, 2011

Summary

This summary is machine-generated.

Habitual knuckle cracking (KC) does not appear to increase the risk of developing hand osteoarthritis (OA). This study found no significant correlation between knuckle cracking habits and the presence or severity of hand OA.

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Area of Science:

Rheumatology
Orthopedics
Epidemiology

Background:

Previous research has yielded conflicting results regarding the link between knuckle cracking (KC) and hand osteoarthritis (OA).
Some studies found no correlation, while one suggested an inverse relationship with metacarpophalangeal joint OA.

Purpose of the Study:

To investigate the association between habitual knuckle cracking and the presence of hand osteoarthritis.
To determine if the duration or frequency of knuckle cracking influences the risk of developing hand OA.

Main Methods:

A retrospective case-control study was conducted involving 215 participants aged 50-89 years.
Participants were categorized into hand OA patients (n=135) and controls (n=80) based on radiographic evidence.
Data on knuckle cracking habits (frequency, duration) and OA risk factors were collected.

Main Results:

The prevalence of knuckle cracking was 20% among respondents.
No significant difference in overall hand OA prevalence was observed between knuckle crackers (18.1%) and non-crackers (21.5%).
Neither the duration nor the cumulative volume of knuckle cracking showed a significant correlation with OA in specific joints.

Conclusions:

Habitual knuckle cracking, regardless of duration or cumulative exposure, does not appear to be a risk factor for hand osteoarthritis.
The findings suggest that knuckle cracking is not causally linked to the development of hand OA.