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Related Experiment Video

Updated: Jun 3, 2026

PTR-ToF-MS Coupled with an Automated Sampling System and Tailored Data Analysis for Food Studies: Bioprocess Monitoring, Screening and Nose-space Analysis

PTR-ToF-MS Coupled with an Automated Sampling System and Tailored Data Analysis for Food Studies: Bioprocess Monitoring, Screening and Nose-space Analysis

Published on: May 11, 2017

On-line breath analysis with PTR-TOF.

Jens Herbig¹, Markus Müller, Simon Schallhart

¹Ionimed Analytik GmbH, Innsbruck, Austria.

Journal of Breath Research

|March 9, 2011

Summary

This summary is machine-generated.

This study introduces a new proton-transfer-reaction time-of-flight mass spectrometer (PTR-TOF) for sensitive on-line breath analysis. The advanced instrument accurately identifies volatile organic compounds in exhaled breath at parts-per-trillion levels.

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PTR-ToF-MS Coupled with an Automated Sampling System and Tailored Data Analysis for Food Studies: Bioprocess Monitoring, Screening and Nose-space Analysis

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Published on: February 14, 2019

Area of Science:

Analytical Chemistry
Biomedical Engineering
Environmental Science

Background:

Breath gas analysis is crucial for non-invasive diagnostics.
Traditional mass spectrometry methods face limitations in speed and resolution.
Volatile organic compounds (VOCs) in breath offer insights into physiological states.

Purpose of the Study:

To introduce and evaluate a next-generation proton-transfer-reaction time-of-flight mass spectrometer (PTR-TOF) for on-line breath analysis.
To demonstrate the advantages of PTR-TOF for sensitive and rapid detection of VOCs in exhaled breath.
To showcase the capability of high mass resolving power for identifying breath components.

Main Methods:

Utilized a novel proton-transfer-reaction time-of-flight mass spectrometer (PTR-TOF).
Employed buffered end-tidal (BET) sampling for breath collection.
Acquired complete mass spectra within a single exhalation, up to 320 Th.

Main Results:

Achieved sensitive detection of VOCs down to parts-per-trillion (pptv) levels.
Demonstrated rapid acquisition of full mass spectra within fractions of a second.
Successfully separated isobaric molecules using high mass resolving power.
Identified main VOC components in the breath of healthy volunteers.

Conclusions:

PTR-TOF represents a significant advancement for on-line breath analysis.
The instrument's speed and resolution enable detailed characterization of breath composition.
This technology holds promise for improved non-invasive disease diagnostics and physiological monitoring.