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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

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Bronchoprovocation testing in asthma: effect on exhaled monoxides.

Jigme M Sethi¹, Anna M White, Sanjay A Patel

¹Division of Pulmonary and Critical Care Medicine, The Warren Alpert Medical School of Brown University, Providence, RI, USA. jsethi@lifespan.org

Journal of Breath Research

|March 9, 2011

Summary

This summary is machine-generated.

Exhaled carbon monoxide (CO) and nitric oxide (NO) levels change during asthma challenges. Allergen exposure increases exhaled NO, while bronchoconstriction from methacholine decreases both CO and NO.

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Area of Science:

Respiratory Medicine
Allergy and Immunology
Pulmonary Physiology

Background:

Exhaled carbon monoxide (CO) and nitric oxide (NO) are biomarkers for asthma.
Their behavior during different types of airway challenges is not fully understood.
Understanding these kinetics can improve asthma monitoring.

Purpose of the Study:

To compare the effects of allergen and methacholine challenges on exhaled CO and NO.
To investigate the impact of inflammatory versus non-inflammatory stimuli on these gases.
To assess the relationship between bronchospasm and exhaled CO/NO levels.

Main Methods:

Adults with atopic asthma underwent allergen or methacholine challenges.
Healthy controls received a mock challenge.
Spirometry, mixed-expired CO, end-expiratory CO, and end-expiratory NO were measured pre-, during, and post-challenge.

Main Results:

Allergen challenge decreased exhaled CO levels.
Methacholine challenge also decreased exhaled CO levels.
Allergen challenge increased end-expiratory NO, while methacholine challenge decreased it.

Conclusions:

Bronchospasm affects exhaled CO and NO levels.
Allergen-induced inflammation specifically increases exhaled NO.
Exhaled CO and NO measurements may require normalization to FEV(1) for clinical interpretation.