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Updated: Jun 3, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Transcriptional regulation of cellular senescence

F Lanigan1, J G Geraghty, A P Bracken

  • 1Smurfit Genetics Department, The Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.

Oncogene
|March 9, 2011
PubMed

Insights

Cellular senescence, a permanent cell cycle arrest, prevents tumor growth. This review examines transcriptional regulators in senescence, their cancer-related disruptions, and therapeutic potential.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Cellular senescence is a state of irreversible cell cycle arrest.
  • It is triggered by cellular stressors like DNA damage and oncogene activation.
  • Senescence acts as a tumor suppressor mechanism, impeding cancer progression.

Purpose of the Study:

  • To review the role of transcriptional regulators in controlling cellular senescence.
  • To explore how these regulators are altered in cancer.
  • To discuss the therapeutic implications of targeting senescence pathways in cancer treatment.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of transcriptional regulators involved in senescence.
  • Examination of their dysregulation in oncogenesis.

Main Results:

  • Transcriptional regulators are key mediators of senescence induction and maintenance.
  • Their aberrant function is frequently observed in various cancers.
  • Understanding these regulators offers insights into cancer development and progression.

Conclusions:

  • Transcriptional regulators play a critical role in cellular senescence and tumor suppression.
  • Targeting these regulators presents a promising avenue for novel cancer therapies.
  • Further research into senescence pathways could yield significant clinical benefits.

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