Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cimetidine: an immunomodulator.

A Kumar1

  • 1Department of Pediatrics and Human Development, Michigan State University, East Lansing 48824.

DICP : the Annals of Pharmacotherapy
|March 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A simple radioassay for detection of antithyroglobulin autoantibodies.

The Indian journal of medical research·1992
Same author

An immunoradiometric assay for measurement of serum thyroglobulin.

The Indian journal of medical research·1992
Same author

Modification of radiosensitivity by the so-called tissue recovery stimulator. I. Radiosensitizing effects of solcoseryl.

Journal of radiation research·1992
Same author

Postnatal laminar development of cholinergic receptors, protein kinase C and dihydropyridine-sensitive calcium antagonist binding in rat visual cortex. Effect of visual deprivation.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·1992
Same author

Cerebral glucose metabolic rates after 30 and 45 minute acquisitions: a comparative study.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·1992
Same author

Resolution of dihydroxyeicosanoates and of dihydroxyeicosatrienoates by chiral phase chromatography.

Analytical biochemistry·1992
Same journal

Eradication of methicillin-resistant Staphylococcus aureus vaginitis with mupirocin.

DICP : the annals of pharmacotherapy·1991
Same journal

Ketorolac formulary restriction and usage evaluation.

DICP : the annals of pharmacotherapy·1991
Same journal

Oral vancomycin-induced rash: case report and review of the literature.

DICP : the annals of pharmacotherapy·1991
Same journal

Imipenem/cilastatin drug utilization evaluation in a large community hospital.

DICP : the annals of pharmacotherapy·1991
Same journal

Pharmacist involvement in Society of Critical Care Medicine.

DICP : the annals of pharmacotherapy·1991
Same journal

Early anticoagulation therapy in deep vein thrombosis.

DICP : the annals of pharmacotherapy·1991
See all related articles

Cimetidine, an H2-receptor antagonist, enhances immune functions by inhibiting suppressor T lymphocytes. While beneficial for certain infections and immune deficiencies, its use requires caution in transplant and autoimmune patients.

Area of Science:

  • Immunology
  • Pharmacology

Background:

  • Suppressor T lymphocytes express histamine2 (H2) receptors, playing a key role in immune system regulation.
  • H2-receptor antagonists, like cimetidine, can modulate immune responses by affecting suppressor cell activity.

Purpose of the Study:

  • To investigate the immunomodulatory effects of cimetidine.
  • To explore the potential therapeutic applications of cimetidine in enhancing immune function and treating specific conditions.

Main Methods:

  • In vivo and in vitro experiments using cimetidine.
  • Evaluation of immune responses in animal models and human patients, including skin-test antigen responses, lymphocyte mitogen stimulation, and clinical outcomes for infections and immune disorders.

Main Results:

Related Experiment Videos

  • Cimetidine demonstrated enhancement of various immunologic functions, including cell-mediated immunity and responses to mitogens.
  • Positive preliminary results were observed in patients with certain viral infections and hypogammaglobulinemia.
  • Dose-related immunoregulatory effects were noted, though consistency varied.

Conclusions:

  • Cimetidine exhibits immunomodulatory properties by inhibiting suppressor T lymphocyte function.
  • Potential therapeutic benefits exist for specific immune-related conditions, but risks are present for transplant and autoimmune patients.
  • Cimetidine should be considered an experimental immunomodulator due to its complex effects.