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Related Experiment Videos

Dermatitis due to intravesical mitomycin C: a delayed-type hypersensitivity reaction?

G B Colver1, J A Inglis, E McVittie

  • 1University Department of Dermatology, Royal Infirmary, Edinburgh.

The British Journal of Dermatology
|February 1, 1990
PubMed
Summary

Mitomycin C instillations can cause skin reactions like eczematous eruptions. These reactions are likely hypersensitivity responses, possibly mediated through the bladder wall, as indicated by patch tests and immune cell presence.

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Area of Science:

  • Immunology
  • Dermatology
  • Urology

Background:

  • Mitomycin C is an alkylating agent used for bladder carcinoma.
  • Repeated intravesical instillations can lead to cystitis and eczematous eruptions on the skin.
  • The hypothesis suggests these skin reactions result from delayed hypersensitivity to Mitomycin C.

Purpose of the Study:

  • To investigate if eczematous eruptions from Mitomycin C are a hypersensitivity reaction.
  • To identify antigen-presenting cells in the bladder wall of affected patients.
  • To confirm sensitization through patch testing.

Main Methods:

  • Immuno-alkaline phosphatase staining to identify CD1+ cells in bladder tissue.
  • Electron microscopy to detect Birbeck granules.

Related Experiment Videos

  • Dermal patch testing with Mitomycin C in patients.

    • Main Results:

    • CD1+ antigen-presenting cells were found in the bladder epithelium and submucosa.
    • Birbeck granules were observed in some bladder cells.
    • Delayed hypersensitivity was demonstrated in 13 of 26 patients via positive patch tests.

    Conclusions:

    • The eczematous eruption associated with Mitomycin C is likely a hypersensitivity reaction.
    • Sensitization to Mitomycin C may occur in the bladder wall.
    • The reaction might be transvesically mediated.