Novel ferrocenyl nitroxide nanoparticles as electron paramagnetic resonance oximetry probes in vitro and in vivo
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Published on: September 26, 2016
Xiao Qiu1, Hongli Zhao, Ronghua Yu
1Shanghai Key Laboratory of Functional Materials Chemistry, and Research Centre of Analysis & Test, East China University of Science & Technology, Shanghai 200237, PR China.
Aims:
In this article we report our recent developments in the field of electron paramagnetic resonance oximetry.
Materials & Methods:
Novel synthesized ferrocenyl nitroxide radicals (FcN)-1-6 were evaluated to determine their electron paramagnetic resonance oxygen responsiveness and reduction resistance. The 3-ferrocenyl-N-(oxyl-2,2,6,6-tetramethylpiperidin-4-yl) butanamide radical (FcN-6), with outstanding electron paramagnetic resonance oxygen sensitivity, was encapsulated in Pluronic F-127 polymeric nanoparticles.
Results:
The nanoparticles exhibited good oxygen sensitivity, long-term stability of responsiveness, targeting to lung, liver and tumor, and low toxicity.
Conclusion:
These features make this novel nanoparticle especially valuable for mapping O₂ concentrations in the body and monitoring the oxygen level inside tissues.
