Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Malnutrition: a highly predictive risk factor of short-term mortality in elderly presenting to the emergency department.

The journal of nutrition, health & aging·2013
Same author

Component-resolved diagnosis with commercially available D. pteronyssinus Der p 1, Der p 2 and Der p 10: relevant markers for house dust mite allergy.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2012
Same author

[Caring for pain in oncology: intensify caution in the elderly].

Revue des maladies respiratoires·2012
Same author

Depth matters: cells grown on nano-porous anodic alumina respond to pore depth.

Nanotechnology·2012
Same author

[Immune profile of elderly patients admitted in a geriatric short care unit].

La Revue de medecine interne·2010
Same author

Jet exhaust particles alter human dendritic cell maturation.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2010
Same journal

Corrigendum: Shells of charge: a density functional theory for charged hard spheres (2016<i>J. Phys. Condens. Matter</i><b>28</b>244006).

Journal of physics. Condensed matter : an Institute of Physics journal·2026
Same journal

Nuclear spin coherence properties of<sup>151</sup>Eu<sup>3+</sup>and<sup>153</sup>Eu<sup>3+</sup>in a Y<sub>2</sub>O<sub>3</sub>transparent ceramic.

Journal of physics. Condensed matter : an Institute of Physics journal·2026
Same journal

Corrigendum: The Hubbard dimer: a density functional case study of a many-body problem (2015<i>J. Phys.: Condens. Matter</i><b>27</b>393001).

Journal of physics. Condensed matter : an Institute of Physics journal·2026
Same journal

Antibonding-induced counterintuitive thermal transport behavior: A first-principles study of quaternary compounds BaCdXF(X=As,P,Sb).

Journal of physics. Condensed matter : an Institute of Physics journal·2026
Same journal

Topological properties of curved spacetime extended Su-Schrieffer-Heeger model.

Journal of physics. Condensed matter : an Institute of Physics journal·2026
Same journal

Influence of lattice expansion on Cr ferromagnetism in Ce<sub>(1-x)</sub>La<sub>(x)</sub>CrGe<sub>3</sub>compounds revealed by atomic-scale measurements.

Journal of physics. Condensed matter : an Institute of Physics journal·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist
07:48

Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist

Published on: April 25, 2018

Early contacts between T lymphocytes and activating surfaces.

E Cretel1, D Touchard, A M Benoliel

  • 1INSERM UMR 600, Laboratory Adhesion and Inflammation, Parc Scientifique de Luminy, Marseille, France.

Journal of Physics. Condensed Matter : an Institute of Physics Journal
|March 10, 2011
PubMed
Summary
This summary is machine-generated.

Human T lymphocytes analyze surfaces through membrane undulations, forming transient contacts before spreading. This cell behavior integrates surface information for rapid decision-making on activating surfaces.

More Related Videos

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics
09:25

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

Published on: December 24, 2015

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue
06:27

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue

Published on: July 30, 2018

Related Experiment Videos

Last Updated: Jun 3, 2026

Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist
07:48

Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist

Published on: April 25, 2018

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics
09:25

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

Published on: December 24, 2015

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue
06:27

Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue

Published on: July 30, 2018

Area of Science:

  • Cell biology
  • Immunology
  • Biophysics

Background:

  • Cells dynamically interact with their environment to adapt behavior.
  • Understanding how cells analyze surfaces and make decisions is crucial.

Purpose of the Study:

  • To investigate how human T lymphocytes analyze surfaces and process information for attachment decisions.
  • To elucidate the early events of T lymphocyte-surface interactions.

Main Methods:

  • Monitoring human T lymphocyte attachment to antibody-coated surfaces (anti-CD3 and anti-HLA).
  • Utilizing interference reflection microscopy for high-resolution, real-time monitoring of cell-surface apposition.
  • Analyzing vertical membrane undulations and contact area dynamics.

Main Results:

  • A lag phase of tens of seconds precedes contact extension after cell-surface contact.
  • Transient contacts are generated by membrane undulations during the lag phase.
  • Contact area increases linearly post-lag, with faster rates on activating surfaces (1.5 µm²/s) versus control surfaces (0.2 µm²/s).
  • The distance between cell membranes and surfaces decreases during lateral spreading.

Conclusions:

  • Cell spreading on activating surfaces is a rapid process.
  • This rapid spreading is likely driven by the integration of information from transient contacts formed by membrane undulations.
  • The findings support a model where early cell-surface interactions inform subsequent adhesion dynamics.