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DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions
10:05

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Published on: August 26, 2014

Diffusion tensor imaging in preterm infants with punctate white matter lesions.

Laura Bassi1, Andrew Chew, Nazakat Merchant

  • 1Department of Maternal and Paediatric Sciences, Fondazione IRCCS a Grande Ospedale Maggiore Policlinico, University of Milan, Milano 20122, Italy.

Pediatric Research
|March 10, 2011
PubMed
Summary

Preterm infants with punctate white matter (WM) lesions show altered WM microstructure in key motor pathways. Lesion load correlates with reduced fractional anisotropy (FA) in corticospinal tracts.

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Area of Science:

  • Neuroimaging
  • Developmental Neuroscience
  • Pediatric Neurology

Background:

  • Preterm birth is associated with white matter (WM) abnormalities.
  • Punctate WM lesions are a common finding in preterm infants.
  • The impact of these lesions on developing WM microstructure is not fully understood.

Purpose of the Study:

  • To compare WM microstructure between preterm infants with and without punctate WM lesions.
  • To investigate the relationship between lesion load and WM microstructure integrity.

Main Methods:

  • Tract-based spatial statistics (TBSS) and probabilistic tractography were used.
  • 23 preterm infants with punctate lesions and 23 matched controls were studied.
  • Fractional anisotropy (FA) was assessed at term equivalent age.

Main Results:

  • Significantly lower FA was observed in the punctate lesion group in several WM tracts, including the corticospinal tract.
  • A negative correlation was found between the number of lesions and FA in the corticospinal tracts.
  • The posterior limb of the internal capsule and cerebral peduncles showed reduced FA.

Conclusions:

  • Punctate WM lesions in preterm infants are associated with altered WM microstructure.
  • These microstructural changes affect critical motor pathways like the corticospinal tract.
  • Lesion load is a significant factor in the degree of microstructural alteration.