Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

8.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.6K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

2.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
2.7K
Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

5.7K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
5.7K
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

3.7K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.7K
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

67
Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the...
67
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

58
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features...
58

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Arginine or Hypertonic Saline-Stimulated Copeptin to Diagnose AVP Deficiency.

The New England journal of medicine·2023
Same author

[Personalized treatment of pheochromocytoma].

Chirurgie (Heidelberg, Germany)·2023
Same author

Endocrine Disruptors: Focus on the Adrenal Cortex.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2023
Same author

Comorbidities in mild autonomous cortisol secretion and the effect of treatment: systematic review and meta-analysis.

European journal of endocrinology·2023
Same author

Somatostatin Receptor-Directed PET/CT Can Differentiate Between Different Subtypes of Head and Neck Paragangliomas.

Clinical nuclear medicine·2023
Same author

Asymmetric Adrenals: Sexual Dimorphism of Adrenal Tumors.

The Journal of clinical endocrinology and metabolism·2023

Related Experiment Video

Updated: May 6, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

26.6K

Adrenocortical carcinoma: a clinician's update.

Martin Fassnacht1, Rossella Libé, Matthias Kroiss

  • 1Department of Internal Medicine I, Endocrine Unit, University Hospital, University of Würzburg, Oberdürrbacher Straße 6, 97080 Würzburg, Germany. fassnacht_m@medizin.uni-wuerzburg.de

Nature Reviews. Endocrinology
|March 10, 2011
PubMed
Summary

Adrenocortical carcinoma is a rare cancer. Key factors include IGF-2 and beta-catenin. Early diagnosis and treatment, including surgery and mitotane, improve outcomes for this aggressive neoplasm.

More Related Videos

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.1K
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

2.6K

Related Experiment Videos

Last Updated: May 6, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

26.6K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.1K
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

2.6K

Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Adrenocortical carcinoma (ACC) is a rare, aggressive cancer with poor prognosis.
  • Overexpression of insulin-like growth factor 2 (IGF-2) and activated beta-catenin are implicated in ACC development.
  • Patients often present with hormone excess or mass effects, but incidental diagnoses are increasing.

Purpose of the Study:

  • To summarize current understanding and management of adrenocortical carcinoma.
  • To highlight diagnostic and therapeutic challenges and advancements.
  • To discuss the role of multidisciplinary collaboration and emerging therapies.

Main Methods:

  • Review of existing literature and collaborative network findings (e.g., ENSAT).
  • Emphasis on endocrine and imaging work-up for surgical planning.
  • Inclusion of pathological markers (Weiss score, Ki67) for malignancy assessment.

Main Results:

  • Complete surgical resection is the primary goal for suspected ACC.
  • Adjuvant mitotane is beneficial for most patients; it's a cornerstone for metastatic disease.
  • Close follow-up is crucial due to high recurrence rates.

Conclusions:

  • Multidisciplinary collaboration has advanced ACC management.
  • Standardized diagnostic and therapeutic approaches are evolving.
  • Targeted therapies, like IGF-1 receptor inhibitors, show promise for future treatment.