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Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments
Published on: January 23, 2018
Ball milling in organic synthesis: solutions and challenges
Achim Stolle1, Tony Szuppa, Silke E S Leonhardt
1Institute for Technical Chemistry and Environmental Chemistry, Friedrich-Schiller University Jena, Lessingstr. 12, D-07743 Jena, Germany. Achim.Stolle@uni-jena.de
Chemical Society Reviews
|March 10, 2011
Summary
Ball milling is an underrepresented yet powerful technique in organic synthesis. This review highlights its potential as a sustainable method for chemical reactions, encouraging wider adoption in laboratories.
Area of Science:
- Organic Chemistry
- Sustainable Synthesis
- Green Chemistry
Background:
- Ball milling has emerged as a significant technique in organic synthesis over the past decade.
- Despite its growing potential, its application is underrepresented compared to other sustainable methods like microwave or ultrasound.
- Recent years have seen a surge in high-quality synthetic procedures utilizing ball milling.
Purpose of the Study:
- To review key advancements in organic synthesis achieved through ball milling.
- To highlight ball milling as an effective method for energy transfer and dissipation in chemical reactions.
- To encourage organic chemists to integrate ball milling into routine laboratory practices.
Main Methods:
- Focus on tutorial review of published protocols.
- Emphasis on energy transfer and dissipation mechanisms in ball milling.
- Showcasing diverse applications across organic synthesis.
Main Results:
- Ball milling offers a versatile and sustainable approach to organic synthesis.
- Numerous high-quality synthetic procedures have been developed using this technique.
- The method is applicable to a wide range of organic transformations.
Conclusions:
- Ball milling represents a valuable tool for sustainable organic synthesis.
- Increased adoption of ball milling can advance green chemistry practices.
- Further research and implementation are encouraged to explore its full potential.
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