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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Related Experiment Video

Updated: Jun 3, 2026

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
06:27

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

Published on: October 20, 2020

Controllable exploding microcapsules as drug carriers.

Jing Zhang1, Cao Li, Ya Wang

  • 1Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, 430072, PR China.

Chemical Communications (Cambridge, England)
|March 10, 2011
PubMed
Summary

Researchers created controllable exploding microcapsules using layer-by-layer assembly. These polyelectrolyte microcapsules release drugs explosively when triggered by DTT.

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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
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Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Drug Delivery

Background:

  • Layer-by-layer assembly is a versatile technique for creating multilayered structures.
  • Developing triggered drug release systems is crucial for targeted therapies.
  • Microcapsules offer a promising platform for encapsulating and delivering therapeutic agents.

Purpose of the Study:

  • To develop novel, controllable exploding polyelectrolyte microcapsules.
  • To investigate the use of click chemistry for fabricating microcapsule cores.
  • To achieve triggered drug release via disulfide bond cleavage.

Main Methods:

  • Fabrication of dextran microgel cores using click chemistry with cleavable disulfide bonds.
  • Layer-by-layer assembly of poly(allylamine hydrochloride) (PAH) and poly(sodium 4-styrenesulfonate) (PSS) on microgel cores.
  • Induction of microcapsule explosion and drug release using dithiothreitol (DTT).

Main Results:

  • Successfully developed polyelectrolyte microcapsules with a dextran microgel core.
  • Demonstrated controllable explosion of microcapsules upon DTT injection.
  • Achieved rapid and explosive release of encapsulated drug cargo.

Conclusions:

  • The developed microcapsules provide a controllable platform for triggered drug release.
  • Click chemistry and layer-by-layer assembly are effective for creating stimuli-responsive drug delivery systems.
  • Exploding microcapsules show potential for enhanced therapeutic efficacy through rapid drug delivery.