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Changes in haemostatic and platelet activation markers in non-dipper hypertensive patients

Athanasia Agorasti1, Efthimia Mourvati, Theodoros Trivellas

  • 1Department of Haematology Laboratory, General Hospital of Xanthi, Ephessou 68, 67100 Xanthi, Greece. vhrissan@civil.duth.gr

International Urology and Nephrology
|March 10, 2011
PubMed

Insights

Non-dipper hypertensive patients show higher levels of key blood clotting and fibrinolysis markers. These haemostatic alterations in non-dippers may contribute to their increased cardiovascular disease risk.

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Hemostasis and Thrombosis

Background:

  • Non-dipper hypertension is a recognized risk factor for cardiovascular disease.
  • Activation of coagulation and fibrinolysis pathways are implicated in cardiovascular risk.
  • Understanding haemostatic differences in non-dippers is crucial for risk stratification.

Purpose of the Study:

  • To investigate the relationship between haemostatic and platelet activation markers and the non-dipping blood pressure pattern.
  • To compare coagulation and fibrinolysis markers in treated hypertensive patients with and without the non-dipping pattern.

Main Methods:

  • Seventy-one treated hypertensive patients were categorized as dippers or non-dippers based on 24-hour ambulatory blood pressure monitoring.
  • Plasma levels of coagulation factors (VIII, IX, fibrinogen), activation markers (prothrombin fragment 1+2, thrombin-antithrombin complex), and fibrinolysis markers (protein C, plasmin-alpha-2-antiplasmin complex, D-dimer) were measured.
  • Platelet factor 4 was also assessed as a marker of platelet activation.

Main Results:

  • Non-dipper hypertensive patients exhibited significantly higher plasma levels of factors VIII and IX, fibrinogen, prothrombin fragment 1+2, protein C, plasmin-alpha-2-antiplasmin complex, and D-dimers compared to dippers.
  • No significant differences were observed in thrombin-antithrombin complex or platelet factor 4 levels between the groups.
  • These findings indicate widespread alterations in haemostasis among non-dipper hypertensive individuals.

Conclusions:

  • Treated hypertensive patients with a non-dipping blood pressure pattern demonstrate significant alterations in haemostatic and fibrinolytic markers.
  • These haemostatic changes in non-dippers may contribute to their elevated risk of cardiovascular events.
  • Further research is warranted to explore therapeutic strategies targeting these haemostatic pathways in non-dipper hypertension.
Abstract

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