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Updated: Jun 3, 2026

Focal Ca2+ Transient Detection in Smooth Muscle
Published on: June 29, 2009
Functional modeling of the shift in cellular calcium dynamics at the onset of synchronization in smooth muscle cells
D E Postnov1, J C Brings Jacobsen, N-H Holstein-Rathlou
1Department of Physics, Saratov State University, Astrakhanskaya Str. 83, Saratov, 410026, Russia.
Abstract:
In the present paper we address the nature of synchronization properties found in populations of mesenteric artery smooth muscle cells. We present a minimal model of the onset of synchronization in the individual smooth muscle cell that is manifested as a transition from calcium waves to whole-cell calcium oscillations. We discuss how different types of ion currents may influence both amplitude and frequency in the regime of whole-cell oscillations. The model may also explain the occurrence of mixed-mode oscillations and chaotic oscillations frequently observed in the experimental system.
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