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Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...

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Empagliflozin in De Novo vs Acute Decompensated Chronic Heart Failure: A Prespecified Analysis From EMPULSE.

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Related Experiment Video

Updated: Jun 3, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
07:24

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

Androgen deficiency in heart failure.

Gülmisal Güder1, Bruno Allolio, Christiane E Angermann

  • 1Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.

Current Heart Failure Reports
|March 10, 2011
PubMed
Summary

Androgen deficiency, common in chronic diseases like heart failure, may worsen symptoms. Testosterone replacement therapy shows potential for improving physical performance but requires careful benefit-risk assessment.

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A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
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A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

Related Experiment Videos

Last Updated: Jun 3, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
07:24

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

Area of Science:

  • Endocrinology
  • Cardiology
  • Geriatrics

Background:

  • Androgen deficiency is prevalent in advanced chronic conditions, potentially causing or resulting from disease.
  • Symptoms like fatigue and muscle weakness are exacerbated in heart failure, influenced by low androgen levels.
  • Low androgens can indirectly impact heart failure severity.

Purpose of the Study:

  • To review the cardiovascular effects of androgens.
  • To outline potential benefits of testosterone replacement therapy (TRT) in heart failure patients.
  • To identify suspected side effects of TRT in this population.

Main Methods:

  • Literature review of androgen effects on the cardiovascular system.
  • Analysis of pilot trials on TRT for heart failure symptoms.
  • Assessment of the benefit-risk ratio of TRT in elderly patients.

Main Results:

  • Pilot trials suggest modest improvements in physical performance with TRT.
  • Androgen deficiency is linked to worsened heart failure symptoms.
  • Risks associated with testosterone replacement in elderly patients are not fully elucidated.

Conclusions:

  • Testosterone replacement therapy is a potential adjunct treatment for heart failure symptoms.
  • The benefit-risk profile of TRT in heart failure patients, especially the elderly, remains unclear.
  • Further research is needed to clarify the role and safety of TRT in managing heart failure.