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Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

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[Hydroxyurea induced-leg ulcer in polycythemia vera].

Aida Khaled¹, Nadia El Guellali, Lamia Aissaoui

¹Service de Dermatologie, Hôpital Charles Nicolle de Tunis, Université Tunis El Manar, Tunis, Tunisie.

La Tunisie Medicale

|March 10, 2011

Summary

Hydroxyurea (HU) can cause rare but serious leg ulcers in patients with myeloproliferative disorders. Discontinuing HU treatment is the most effective way to achieve complete healing of these ulcers.

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Area of Science:

Dermatology
Pharmacology
Hematology

Background:

Hydroxyurea (HU) is an antineoplastic drug used for myeloproliferative disorders.
Dermatological side effects are common but typically benign.
Leg ulceration is a rare complication of HU therapy.

Observation:

A case study of a 70-year-old woman with polycythemia vera treated with HU.
The patient developed painful malleolar ulcers one year after starting HU.
Ulcers recurred after initial healing, becoming multiple and bilateral.

Findings:

Hydroxyurea-induced leg ulcers are rare and their pathogenesis is multifactorial.
Discontinuation of hydroxyurea treatment led to complete ulcer recovery in the reported case.
This highlights a significant, albeit uncommon, adverse effect of hydroxyurea.

Implications:

Clinicians should consider hydroxyurea-induced leg ulcers in patients presenting with such symptoms.
Discontinuation of HU should be strongly considered for managing these ulcers.
Further research into the pathogenesis of HU-induced ulcers is warranted.