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Published on: July 14, 2023
Hypocalcaemia due to hypoparathyroidism in β-thalassemia major. A study of a new case
Nawel Dhouib1, Zinet Turki, Fethi Mellouli
1Centre National de Greffe de Moelle Osseuse, Tunis.
Aim:
To report a new case of hypoparathyroidism in a child with ß-thalassemia major
Case:
We report a case of a 17-year-old Tunisian girl with transfusion-dependent thalassemia major presented with paresthesia and pubertal delay. Laboratory investigations showed hypocalcaemia and hyperphosphatemia. Parathyroid hormone level was low (2 ng/l, normal range: 12-72 ng/l) than expected for the degree of hypocalcaemia. Serum ferritin concentration was 1770ng/ml. The patient was started on oral daily calcium supplementation, Alfa calciferol and intensive iron chelation therapy. Follow-up after 6 and 12 months revealed normal Calcium and ECG showed QT interval within normal range.
Conclusion:
Investigating calcium homeostasis at regular intervals and early management of any abnormality can preclude the occurrence of complications.
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