Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Eco-evolutionary Guided Pathomics Analysis to Predict DCIS Upstaging.

bioRxiv : the preprint server for biology·2024
Same author

L-DOS47 Elevates Pancreatic Cancer Tumor pH and Enhances Response to Immunotherapy.

Biomedicines·2024
Same author

L-DOS47 enhances response to immunotherapy in pancreatic cancer tumor.

bioRxiv : the preprint server for biology·2023
Same author

Intraperitoneal Delivery of Iopamidol to Assess Extracellular pH of Orthotopic Pancreatic Tumor Model by CEST-MRI.

Contrast media & molecular imaging·2023
Same author

Evolutionary Analysis of TCGA Data Using Over- and Under- Mutated Genes Identify Key Molecular Pathways and Cellular Functions in Lung Cancer Subtypes.

Cancers·2023
Same author

Model-constrained reconstruction accelerated with Fourier-based undersampling for hyperpolarized [1-<sup>13</sup> C] pyruvate imaging.

Magnetic resonance in medicine·2022
Same journal

Reproducibility of Splanchnic Blood Flow Measured Using Phase-Contrast MRI.

NMR in biomedicine·2026
Same journal

Restriction-Weighted Q-Space Trajectory Imaging (ResQ): Toward Mapping Diffusion-Time Effects With Tensor-Valued Diffusion Encoding in Human Prostate Cancer Xenografts.

NMR in biomedicine·2026
Same journal

In Vivo Quantitative Detection of PEGylated Macromolecules by Magnetic Resonance Spectroscopy.

NMR in biomedicine·2026
Same journal

Metabolic Assessment in Human Pluripotent Stem Cell-Derived Cerebral Organoids Using HR-MAS NMR Spectroscopy.

NMR in biomedicine·2026
Same journal

Characterizing Metabolic and Compositional Heterogeneity of Calf Muscle Using CEST MRI at 3 T.

NMR in biomedicine·2026
Same journal

Estimating the Sodium Content: A Case Series of Benign and Malignant Renal Tumours Using <sup>23</sup>Na-MRI at 3 T.

NMR in biomedicine·2026
See all related articles

Related Experiment Video

Updated: Jun 3, 2026

Ex vivo Live Imaging of Lung Metastasis and Their Microenvironment
11:19

Ex vivo Live Imaging of Lung Metastasis and Their Microenvironment

Published on: February 3, 2016

Imaging pH and metastasis.

Arig Ibrahim Hashim1, Xiaomeng Zhang, Jonathan W Wojtkowiak

  • 1Department of Imaging research, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

NMR in Biomedicine
|March 10, 2011
PubMed
Summary
This summary is machine-generated.

Tumor acidity, a hallmark of the tumor microenvironment, significantly drives cancer metastasis. Advanced magnetic resonance (MR) imaging techniques can now map this acidity, revealing its crucial role in tumor progression and immune evasion.

More Related Videos

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
07:44

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

In Vivo Imaging to Measure Spontaneous Lung Metastasis of Orthotopically-injected Breast Tumor Cells
08:36

In Vivo Imaging to Measure Spontaneous Lung Metastasis of Orthotopically-injected Breast Tumor Cells

Published on: June 23, 2022

Related Experiment Videos

Last Updated: Jun 3, 2026

Ex vivo Live Imaging of Lung Metastasis and Their Microenvironment
11:19

Ex vivo Live Imaging of Lung Metastasis and Their Microenvironment

Published on: February 3, 2016

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
07:44

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

In Vivo Imaging to Measure Spontaneous Lung Metastasis of Orthotopically-injected Breast Tumor Cells
08:36

In Vivo Imaging to Measure Spontaneous Lung Metastasis of Orthotopically-injected Breast Tumor Cells

Published on: June 23, 2022

Area of Science:

  • Oncology
  • Medical Imaging
  • Cancer Biology

Background:

  • Metastasis involves tumor cells invading local tissues, entering circulation, and colonizing distant organs.
  • The tumor microenvironment, particularly its acidic extracellular pH (low pH), significantly influences tumor progression and metastasis.
  • Tumor acidity arises from high glycolysis and poor perfusion in solid tumors, distinguishing them from normal tissues.

Purpose of the Study:

  • To review magnetic resonance (MR)-based methods for non-invasively measuring tumor pH.
  • To emphasize the critical role of extracellular tumor acidity in various metastatic steps.
  • To highlight the impact of tumor acidity on epithelial-to-mesenchymal transition (EMT) and anti-cancer immunity.

Main Methods:

  • Review of technological advancements in non-invasive intra- and extracellular pH measurement.
  • Focus on MR-based techniques, detailing improvements in sensitivity and accuracy.
  • Analysis of how quantitative pH imaging aids understanding of tumor microenvironment's role.

Main Results:

  • Significant advancements in MR-based techniques enable accurate and sensitive measurement of tumor pH.
  • Extracellular tumor acidity is implicated in multiple stages of the metastatic cascade.
  • Low tumor pH influences key processes like epithelial-to-mesenchymal transition (EMT) and immune responses.

Conclusions:

  • Quantitative imaging of tumor acidity using MR provides critical insights into cancer progression.
  • Understanding the role of tumor microenvironment acidity is vital for developing anti-cancer strategies.
  • Targeting tumor acidity may offer novel therapeutic approaches to inhibit metastasis and enhance anti-cancer immunity.