[Percutaneous coronary intervention and stent thrombosis]

Area of Science:

• Cardiology
• Interventional Cardiology
• Biomedical Engineering

Context:

• Stent thrombosis is a rare but severe complication following percutaneous coronary intervention (PCI).
• Despite technological advancements and antiplatelet therapies, stent thrombosis remains a significant concern.
• The event is often linked to major adverse cardiac events, including myocardial infarction (MI) and death.

Purpose:

• To characterize late (31 days to 1 year) and very late (>1 year) stent thrombosis.
• To address the uncertainty surrounding the optimal duration of dual antiplatelet therapy (DAPT) for patients with drug-eluting stents (DES).

Summary:

• Stent thrombosis is categorized as early (0-30 days), late (31 days-1 year), and very late (>1 year).
• Late and very late stent thrombosis are not well-characterized due to their low incidence.
• The optimal duration of DAPT for patients receiving DES is still uncertain.

Impact:

• Improved understanding of late and very late stent thrombosis can guide clinical practice.
• This knowledge may lead to refined DAPT strategies, potentially reducing the incidence of stent thrombosis.
• Enhanced patient safety and long-term outcomes after PCI with stent implantation.