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Related Experiment Video

Updated: Jun 3, 2026

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
06:23

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

[Bladder cancer biomarkers].

Barbara Dobrowolska-Glazar1, Wojciech Glazar, Zygmunt Dobrowolski

  • 1Katedra i Klinika Urologii Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków. bdobrowolska@o2.pl

Przeglad Lekarski
|March 11, 2011
PubMed
Summary

Bladder cancer frequently recurs, necessitating effective surveillance. Current non-invasive urine tests lack sensitivity, while cystoscopy is invasive, highlighting the need for improved bladder cancer markers.

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Area of Science:

  • Oncology
  • Urology

Context:

  • Bladder cancer is a prevalent malignancy with high recurrence rates for non-muscle invasive types.
  • Close surveillance is crucial for early detection of recurrent bladder tumors.
  • Existing diagnostic methods like urine cytology have low sensitivity, and cystoscopy is invasive and costly.

Purpose:

  • To review current non-invasive urine markers for bladder cancer detection and surveillance.
  • To highlight the limitations of existing bladder cancer surveillance methods.
  • To discuss the ongoing search for sensitive and specific urinary biomarkers for bladder cancer.

Summary:

  • Urine cytology, a common non-invasive test for urothelial tumors, suffers from low sensitivity.
  • While many novel urinary markers show improved sensitivity over cytology for bladder cancer detection, they often lack specificity.
  • Currently, no clinically validated molecular markers exist to guide bladder cancer diagnosis, surveillance, or reduce cystoscopy frequency.

Impact:

  • Identifies the critical need for developing accurate, non-invasive biomarkers for bladder cancer surveillance.
  • Discusses the limitations of current diagnostic tools, emphasizing the gap in clinical practice.
  • Provides an overview of prominent urine markers currently under investigation for bladder cancer management.

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Last Updated: Jun 3, 2026

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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019