[Metabolic changes in bone marrow in patients submitted to immunosuppressive treatment]

A historical outline of the immunosuppressive treatment and related developments in transplantology is presented here. It is accompanied by a description of the essential knowledge of the bone marrow histology as well as of the role of mesenchymal stem cells (MSCs) in the regenerative processes occurring in the organism following tissue damage. We have reviewed contemporary knowledge of negative (quantitative and qualitative) changes in bone tissues caused by immunosuppressive treatment after an organ transplantation and mentioned prophylactic measures which may be used in such cases. We also describe basic immunosuppressive medications taking into account their side effects on the organism of the patient and, in particular, on the bone marrow metabolism as well as the mechanisms of their action at the cellular level.