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Updated: Jun 3, 2026
11:38
High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
Published on: May 10, 2016
[Toxicity of sulpiride].
Krzysztof Ciszowski1, Dorota Szpak, Jolanta Wilimowska
1Klinika Toksykologii i Chorób Srodowiskowych, Katedry Toksykologii Klinicznej i Srodowiskowej UJ CM w Krakowie. wt_poohatek@wp.pl
Przeglad Lekarski
|March 11, 2011
Summary
Sulpiride poisoning can cause severe neuropsychiatric and cardiac issues, including dangerous heart rhythm problems and neuroleptic malignant syndrome. Prompt treatment focuses on decontamination and supportive care for these critical sulpiride overdose effects.
Area of Science:
- Pharmacology
- Neuroscience
- Toxicology
Context:
- Sulpiride, a benzamide neuroleptic, treats psychiatric and gastroenterological disorders.
- Its mechanism involves antagonism of dopaminergic D2, D3, and D4 receptors in the central nervous system (CNS).
- Poor oral bioavailability and primary renal elimination characterize sulpiride's pharmacokinetics.
Purpose:
- To outline the clinical presentation and management of acute sulpiride poisoning.
- To highlight life-threatening complications such as QTc prolongation, torsade de pointes (TdP), and neuroleptic malignant syndrome (NMS).
- To discuss the limited availability of quantitative sulpiride blood concentration measurements and therapeutic strategies.
Summary:
- Acute sulpiride poisoning manifests with neuropsychiatric symptoms (agitation, hallucinations, CNS depression) and cardiac effects (hypotension, dysrhythmias).
- Life-threatening risks include TdP due to QTc prolongation and NMS, which can be fatal.
- Management involves gastrointestinal decontamination, symptomatic/supportive care, and specific treatments for TdP and NMS.
Impact:
- Informs clinicians about the potential severity of sulpiride overdose.
- Provides guidance on recognizing and managing critical complications.
- Emphasizes the need for supportive care in the absence of routine therapeutic drug monitoring.
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