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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Site-selective binding of nanoparticles to double-stranded DNA via peptide nucleic acid "invasion"

Andrea L Stadler1, Dazhi Sun, Mathew M Maye

  • 1Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA.

ACS Nano
|March 11, 2011
PubMed

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Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...