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Related Concept Videos

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
10:26

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

Gene interaction network regulates plasma cell differentiation.

J Alinikula1, O Lassila

  • 1Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland. jukka.alinikula@utu.fi

Scandinavian Journal of Immunology
|March 11, 2011
PubMed
Summary
This summary is machine-generated.

Humoral immunity relies on B cells differentiating into plasma cells, producing high-affinity antibodies. This process is controlled by transcription factors, with Blimp-1 driving plasma cell formation after germinal center reactions.

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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
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Published on: June 27, 2020

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Humoral immunity is crucial for defense, mediated by B cells, plasma cells, and follicular helper T cells (TFH).
  • High-affinity antibody production follows germinal center (GC) reactions, involving B cell maturation.
  • Transcription factors regulate B cell differentiation into antibody-secreting plasma cells.

Purpose of the Study:

  • To elucidate the transcriptional regulatory network governing B cell differentiation into plasma cells.
  • To understand the initiation of plasma cell differentiation within germinal centers.
  • To clarify the roles of transcription factors like Blimp-1, Pax5, and Bcl6 in this process.

Main Methods:

  • Analysis of transcriptional regulatory networks.
  • Investigating the roles of key transcription factors in B cell differentiation.
  • Studying the germinal center reaction and plasma cell development.

Main Results:

  • Plasma cell differentiation is driven by the transcriptional repressor Blimp-1.
  • Initiation of plasma cell differentiation in GCs is linked to the downregulation of B cell factors Pax5 and Bcl6.
  • A regulatory network of transcription factors controls B cell fate and antibody production.

Conclusions:

  • Blimp-1 is a key driver of plasma cell differentiation.
  • The interplay between transcription factors Pax5, Bcl6, and Blimp-1 is critical for effective humoral immunity.
  • Understanding these regulatory mechanisms enhances knowledge of antibody production and immune responses.