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Silicon-associated subcutaneous lesion presenting as a mass: a confounding histopathologic correlation
Marianna Shvartsbeyn1, Amy Rapkiewicz
1Department of Pathology, New York University, New York, NY 10016, USA. marianna.shvartsbeyn@nyumc.org
Human Pathology
|March 11, 2011
Summary
Liquid silicone injections for soft tissue augmentation can lead to adverse effects. Adulterated industrial-grade silicon may cause granulomas and nodules years after injection, mimicking tumors.
Area of Science:
- Dermatology
- Pathology
- Plastic Surgery
Background:
- Liquid silicone injections are used for soft tissue augmentation.
- The histological outcome depends on silicon purity and injection volume.
- Medical-grade silicon causes minimal fibroplasia, while industrial-grade silicon can lead to complications.
Observation:
- A 35-year-old transsexual woman presented with bilateral buttock masses.
- Histologic evaluation revealed lipid-laden vacuoles resembling lipoblasts.
Findings:
- Industrial-grade liquid silicone, contaminated with additives, can cause delayed adverse effects.
- These effects include extensive granulomas and disfiguring nodules.
- The histological pattern can be misdiagnosed as a neoplastic process.
Implications:
- Adulterated liquid silicone can cause significant disfigurement and complications.
- Delayed adverse effects can mimic neoplastic conditions, complicating diagnosis.
- Awareness of these potential complications is crucial for clinicians managing soft tissue augmentation patients.
