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Pediatric cerebellar stroke associated with elevated titer of antibodies to β2-glycoprotein

Alberto Spalice1, Francesca Del Balzo, Francesco Massimo Perla

  • 1Department of Pediatrics, Division of Child Neurology, University La Sapienza, Roma, Italy. childneurology.sapienzaroma@live.it

Medical Hypotheses
|March 11, 2011
PubMed

Insights

This study reports the first case of childhood cerebellar stroke linked solely to antibodies to 2-glycoprotein I (anti-2GPI), without other antiphospholipid antibodies. This finding highlights a potential new diagnostic consideration for pediatric ischemic stroke.

Area of Science:

  • Pediatric Neurology
  • Immunology
  • Vascular Medicine

Background:

  • Antibodies to 2-glycoprotein I (anti-2GPI) are linked to thrombosis and pregnancy issues.
  • The prevalence of anti-2GPI in pediatric cerebral infarction is not well-established.

Observation:

  • A 10-month-old boy experienced an ischemic cerebellar stroke.
  • The child had high immunoglobulin G anti-2GPI titers.
  • Standard antiphospholipid antibody tests (anticardiolipin and lupus anticoagulant) were negative.

Findings:

  • This case represents the first reported instance of childhood cerebellar ischemic stroke exclusively associated with anti-2GPI.
  • Antiphospholipid syndrome was diagnosed based solely on high anti-2GPI titers.

Implications:

  • This case suggests that anti-2GPI antibodies alone, without other antiphospholipid antibodies, can cause ischemic stroke in children.
  • Pediatric neurologists and immunologists should consider anti-2GPI testing in children with unexplained ischemic stroke.
  • Further research is needed to understand the role and prevalence of anti-2GPI in pediatric cerebrovascular events.

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