Related Experiment Video
Updated: Jun 3, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Severe human parechovirus sepsis beyond the neonatal period
Rebecca Sainato1, Ryan Flanagan, Steven Mahlen
1Tripler Army Medical Center, Department of Pediatrics, ATTN: MCHK-PE, 1 Jarrett White Road, Honolulu, HI 96859, United States. rebecca.sainato@us.army.mil
Abstract:
Here we describe a case of viral sepsis beyond the neonatal period caused by human parechovirus subtype 3 (HPeV-3), which manifested as cardio-respiratory failure, hepatitis, and necrotizing enterocolitis (NEC). HPeV-1 and 2 were originally classified as enteroviruses but the advent of sequence analysis led to them being recognized as a new genus in the picornavirus family. Subsequently, nine additional HPeV strains have been reported including HPeV-3 in 1999.(1) The spectrum of disease that these viruses may cause is still unknown, and they are rarely screened for in clinical practice.
Related Concept Videos
Bacterial Meningitis I: Introduction
Bacterial Meningitis II: Pathophysiology
Pneumonia III: Complications and Assessment
Respiratory Syncytial Virus Disease
Bacterial Meningitis
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:

