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Related Experiment Video

Updated: Jun 3, 2026

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

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Published on: July 28, 2023

Adaptive cytoprotection and the brain-gut axis.

J K S Ko¹, C H Cho

¹Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, SAR, China.

|March 11, 2011

Summary

Adaptive cytoprotection protects the gastric lining from injury via prostaglandins and neural pathways. Newer approaches like ischemic preconditioning offer novel strategies for enhanced mucosal defense.

Area of Science:

Gastroenterology
Physiology
Pharmacology

Background:

Adaptive cytoprotection mitigates gastric mucosal injury from stressors like NSAIDs.
This defense involves complex mediators and signaling pathways.

Purpose of the Study:

To review the mechanisms of adaptive cytoprotection.
To explore the roles of prostaglandins, neural pathways, and newer protective strategies.

Main Methods:

Literature review of studies on adaptive cytoprotection.
Analysis of prostaglandin-dependent and -independent pathways.
Investigation of neuronal modulation involving the vagus nerve and neuropeptides.

Main Results:

Prostaglandins and neural pathways (vagus nerve, sensory neurons) are key to adaptive cytoprotection.

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The hypothalamic-pituitary-adrenal axis, autonomic, and enteric nervous systems interact.

Nitric oxide and neuropeptides are regulated by mild irritants.

Conclusions:

Adaptive cytoprotection is a multifaceted process involving integrated physiological systems.
Emerging concepts like ischemic preconditioning and heat-shock proteins offer new avenues for gastric protection.