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The PreventCD Study design: towards new strategies for the prevention of coeliac disease

Caroline Elisabeth Hogen Esch1, Anna Rosén, Renata Auricchio

  • 1Department of Pediatric Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands. c.e.hogen_esch@lumc.nl

European Journal of Gastroenterology & Hepatology
|March 11, 2011
PubMed

Insights

The PreventCD study investigates infant nutrition, genetics, and environment to understand coeliac disease (CD) risk. Introducing small gluten amounts during breastfeeding may induce tolerance and reduce autoimmune disorders.

Area of Science:

  • Immunology
  • Gastroenterology
  • Pediatrics

Background:

  • PreventCD is a European multicenter study examining coeliac disease (CD) risk factors.
  • Investigates infant nutrition, genetics, immunology, and environmental influences on CD development.
  • Hypothesizes that early, small-dose gluten introduction during breastfeeding can induce tolerance.

Purpose of the Study:

  • To outline the design of the ongoing European coeliac disease research project.
  • To describe the methodology for investigating coeliac disease etiology.
  • To detail the PreventCD study's approach to understanding immune intolerance.

Main Methods:

  • Employs two study designs: a European multicenter prospective, double-blind, randomized dietary-intervention study.
  • Includes a Swedish population-based screening study of 12-year-olds across two birth cohorts.
  • Differentiates infant feeding practices to assess their impact on coeliac disease risk.

Main Results:

  • Data collection is ongoing.
  • Analysis will focus on the relationship between infant feeding, genetic predisposition, and coeliac disease development.
  • The study aims to identify key factors influencing gluten tolerance in infants.

Conclusions:

  • PreventCD is anticipated to clarify genetic and immunological mechanisms underlying immune intolerance.
  • Findings are expected to inform strategies for coeliac disease prevention.
  • The study will contribute to understanding the development of autoimmune disorders.
Abstract

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