Related Experiment Videos
Growth and siderophore production by Bordetella pertussis under iron-restricted conditions
A R Gorringe1, G Woods, A Robinson
1Biologics Division, PHLS Centre for Applied Microbiology and Research, Porton Down, Salisbury, U.K.
FEMS Microbiology Letters
|January 1, 1990
Abstract:
It has been demonstrated that under iron-restricted conditions Bordetella pertussis can obtain iron from iron-saturated human transferrin. Direct contact between B. pertussis and transferrin was not required as B. pertussis was able to acquire iron from transferrin when they were separated by a dialysis membrane. Siderophore activity was detected in supernatants from iron-restricted cultures of B. pertussis, B. bronchiseptica and B. parapertussis. Siderophores were identified as hydroxamates and were produced by both virulent and avirulent strains of B. pertussis.