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Updated: Jun 3, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Use of carbon dioxide as negative contrast agent for magnetic resonance cholangiopancreatography
Ching-Wen Chen1, Yi-Sheng Liu, Chiung-Yu Chen
1Ching-Wen Chen, Yi-Sheng Liu, Hong-Ming Tsai, Shu-Chen Chen, Ming-Tsung Chuang, Department of Diagnostic Radiology, National Cheng Kung University Hospital, Tainan 70428, Taiwan, China.
Aim:
To evaluate the effects of using CO(2) as negative contrast agent in decreasing the overlapping on the pancreaticobiliary system from intestinal fluids.
Methods:
We evaluated the magnetic resonance cholangiopancreatography (MRCP) images in 117 patients divided into two groups (group 1, without taking gas producing crystals to produce CO(2), n = 64; group 2, with CO(2), n = 53) in a 1.5T unit using MRCP sequence. Anatomic locations of intestinal fluids distribution, overlapping with common bile duct (CBD) and pancreatic duct (PD), were evaluated.
Results:
In the group with CO(2), the decrease in distribution of intestinal fluids was significant in the gastric antrum (P = 0.001) and duodenal bulb (P < 0.001), but not in the gastric fundus and body and in the second portion of the duodenum (P = 1.000, P = 0.171, and P = 0.584 respectively). In the group with CO(2), the decrease in overlapping with CBD was significant (P < 0.001), but the decrease in overlapping with PD was not (P = 0.106).
Conclusion:
MRCP with carbon dioxide as negative contrast agent would decrease intestinal fluids in the gastric antrum and duodenal bulb, thereby decreasing overlapping with the CBD.
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