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[Degradation of C1q, the first subcomponent of the complement sequence, by synovial collagenase from patients with
Wiener Klinische Wochenschrift
|October 27, 1978
Insights
High concentrations of RA synovial collagenase degrade human C1q by attacking its collagen-like sequence. Researchers identified a potential cleavage site, comparing it to collagen cleavage sites.
Area of Science:
- Biochemistry
- Immunology
- Molecular Biology
Abstract:
Human C1q is shown to be degraded by high concentrations of RA synovial collagenase (enzyme : substrate ratio 2 : 1). The collagen-like sequence of C1q is attacked by the enzyme. A possible cleavage site is described and compared with the cleavage site in collagen.