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Related Concept Videos

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...

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Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
09:56

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Published on: September 6, 2019

Ionic catch and release oligosaccharide synthesis (ICROS).

Anh-Tuan Tran1, Richard Burden, Daugirdas T Racys

  • 1School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.

Chemical Communications (Cambridge, England)
|March 11, 2011
PubMed
Summary

A new "catch-and-release" method using ionic liquids simplifies oligosaccharide synthesis without chromatography. This efficient strategy is versatile for creating complex glycan structures like beta-linked oligosaccharides.

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Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
09:56

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Published on: September 6, 2019

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
08:46

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

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High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
14:37

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

Published on: July 6, 2012

Area of Science:

  • Carbohydrate Chemistry
  • Organic Synthesis
  • Green Chemistry

Background:

  • Oligosaccharide synthesis is crucial for understanding biological processes.
  • Current synthetic methods often involve complex purification steps like chromatography.
  • Developing efficient and scalable synthesis strategies is an ongoing challenge.

Purpose of the Study:

  • To report a general and efficient chromatography-free strategy for oligosaccharide synthesis.
  • To introduce the ionic-liquid-supported "catch-and-release" strategy for oligosaccharide synthesis (ICROS).
  • To demonstrate the compatibility and versatility of the ICROS method.

Main Methods:

  • Development of an ionic-liquid-supported "catch-and-release" methodology.
  • Integration of the strategy with established glycosylation techniques.
  • Application of protecting group manipulations within the ICROS framework.

Main Results:

  • Successful synthesis of oligosaccharides without the need for chromatography.
  • Demonstrated compatibility of the ICROS strategy with various glycosylation methods.
  • Preparation of diverse β-(1→6) and β-(1→2)-linked glycan structures.

Conclusions:

  • The ICROS strategy offers a general, efficient, and chromatography-free approach to oligosaccharide synthesis.
  • This method is adaptable to current synthetic protocols and protecting group strategies.
  • The demonstrated synthesis of complex glycans highlights the broad applicability of ICROS.