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Updated: Jun 3, 2026

Control of Eating Behavior Using a Novel Feedback System
Published on: May 8, 2018
[Serotonin and hypothalamic control of hunger: a review]
Fernanda de Matos Feijó1, Marcello Casaccia Bertoluci, Cíntia Reis
1Programa de Pós-Graduação em Medicina, Universidade Federal do Rio Grando de Sul, Porto Alegre, RS. femattosfeijo@hotmail.com
The serotonergic system, involving serotonin (5-HT), plays a key role in controlling food intake and satiety. Research highlights its potential as a target for weight management strategies.
Area of Science:
- Neuroscience
- Endocrinology
- Pharmacology
Context:
- The physiological regulation of energy balance is crucial for preventing obesity.
- The serotonergic system, utilizing serotonin (5-HT), is implicated in appetite control.
- Decades of research underscore the link between serotonin and satiety.
Purpose:
- To review the mechanisms by which the serotonergic system influences food intake and satiety.
- To explore the relevance of serotonin signaling in energy homeostasis and obesity.
- To discuss the role of specific serotonin receptors, such as 5-HT2C, in appetite regulation.
Summary:
- Serotonin (5-HT) significantly impacts satiety, making the serotonergic system a target for weight control.
- Different serotonin receptors exhibit distinct functions in modulating hunger and satiety.
- The 5-HT2C receptor is particularly relevant to the interplay between food intake and energy balance.
Impact:
- Provides a comprehensive overview of serotonergic mechanisms in appetite regulation.
- Informs potential therapeutic strategies for obesity and eating disorders.
- Highlights the 5-HT2C receptor as a key player in energy balance control.
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