Reversible posterior leukoencephalopathy induced by carboplatin and etoposide

Area of Science:

• Neurology
• Oncology

Background:

• Reversible posterior leukoencephalopathy syndrome (RPLS) is a rare neurologic condition.
• RPLS typically presents with headache, visual disturbances, altered consciousness, and seizures.

Observation:

• A 69-year-old female patient developed seizures post-chemotherapy.
• The patient received carboplatin and etoposide for small cell lung cancer.

Findings:

• Clinical and radiological findings were consistent with RPLS.
• This presentation is a rare occurrence secondary to this specific chemotherapy regimen.

Implications:

• This case adds to the literature on RPLS associated with cytotoxic chemotherapy.
• Early diagnosis and prompt intervention are crucial for managing RPLS and ensuring neurological recovery.