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Updated: Jun 3, 2026

Identification of Sleeping Beauty Transposon Insertions in Solid Tumors using Linker-mediated PCR
Published on: February 1, 2013
Transgenic animals and the study of cancer
1Neuropeptide Laboratory, Institute of Molecular and Cell Biology, National University of Singapore, Republic of Singapore.
Abstract:
This chapter seeks to outline the strategies being employed to exploit transgenic mice as a tool in the study of cancer. Rather than catalog the many different oncogene and oncogene-promoter combinations that have been introduced into transgenic mice to elicit tumors, I will concentrate on a single system that epitomizes the general approach. That system, pioneered by Philip Leder of Harvard University, is mammary carcinogenesis induced by oncogene expression directed by the Mouse Mammary Tumor Virus (MMTV) enhancer-promoter.
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