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PCR Analysis of CD44 Variants in Tumors
1Department of Chemical Pathology, School of Medicine, Royal Free Hospital, London, UK.
Methods in Molecular Medicine
|March 11, 2011
Abstract:
The CD44 molecule is a transmembrane glycoprotein, it is an acidic, sul fated protein that contains multiple phosphoserine residues and several intrachain disulfide bonds. It is essentially composed of a 37-kDa protein core highly glycosylated by N- and O-linked sugars to form an 85-90-kDa product and is sometimes additionally linked to chondroitin sulfate side chains to produce a 180-220 kDa form on sodium dodecyl sulfate (SDS) gels (1,2).
